A newly identified mechanism shows that the NIPBL-MAU2-glucocorticoid receptor (GR) ternary complex modulates gene expression by facilitating cohesin loading and chromatin structure alteration.

Long-distance gene control, called distal regulation, relies on physically folding DNA and proteins into sophisticated loops. This allows regions far from a gene’s starting point to activate its ...

KYOTO – An international team of researchers has taken an important step toward understanding how gene expression is controlled across the human genome. A new study has comprehensively analyzed ...

Scientists trained AI to predict gene activity, a potentially powerful tool. Researchers hope the AI tool will aid in the development of cell-specific gene therapies to treat diseases such as cancer.

Manipulating Gene Expression to Treat Disease. Several of our scientists study gene regulation in specific cancers, including cancers of the blood, lung, pancreas and prostate. They seek treatment ...

Gene regulation is critical to the development and homeostasis of living beings (Prud’homme et al., 2007).It is controlled by DNA sequences that encode motifs for transcription factors (TFs) to bind ...

This represented a newly found mechanism of gene regulation that was orchestrated by tiny molecules called microRNA. At first, the researchers thought this mechanism might be unique to C. elegans .

Mesophilic prokaryotic Argonautes (pAgos) have the potential to be developed into genome editing tools. Here, the authors report a mesophilic archaeal Ago that is catalytically active and utilizes ...

Epigenome Editing Toolkit Elucidates Gene Regulation Mechanisms. May 9, 2024. A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones ...

In a groundbreaking development, on Jan. 8, 2024, the U.S. Food and Drug Administration (FDA) announced a pilot program called Collaboration on Gene Therapies Global Pilot (CoGenT Global).

New technique efficiently offers insight into gene regulation Date: December 4, 2023 Source: Hubrecht Institute Summary: Researchers have developed a new technique called MAbID.

Key advantages of epigenetic editing. The data presented at ASGCT demonstrate the key advantages of epigenetic editing for multiplex gene regulation compared to Cas9-based approaches, continued Myer.