Metal-organic frameworks (MOFs) are characterized by high porosity and structural versatility. They have enormous potential, ...

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ROS1 and ALK are promising targets of anticancer drugs for non-small-cell lung cancer. Since they have 49% amide acid sequence homology in the kinases domain and 77% identity at the ATP binding area, ...

Glycosaminoglycans (GAGs) are essential polysaccharides crucial for various cellular functions, such as cell proliferation, migration, and differentiation. However, their complex structure and ...

The N-terminal translocase domain specifically recognizes DNA junctions through multiple key elements, while the C-terminal FAAP24-binding domain engages adjacent double-stranded DNA. Our results ...

A phase 2 trial found that adding bevacizumab to alectinib significantly delayed disease progression, protected against brain metastases, and improved quality of life in patients with advanced ...

In structural terms, ferlins arguably possess the most unique and complex architecture among the known Ca 2+-sensitive C 2-domain factors (Lek et al, 2012; Pangrsic et al, 2012).The ferlin ...

Quantifying clinical harm and financial waste from failure to deploy personalized medicine for patients with metastatic non-small cell lung cancer in the United States. This is an ASCO Meeting ...

Background: Alectinib is a next generation oral inhibitor of ALK-fusion proteins, being investigated in children and adolescents with ALK-fusion bearing tumors at diagnosis or relapse. Here we present ...

Here, we present a strategy to engineer potent, protease-stable single-domain antibodies to enable oral delivery. ... Y. Bloch et al., Structural Activation of pro-inflammatory human cytokine IL-23 by ...