Liu et al. discover amide-forming enzymes in the biosynthesis of E-64, a classic cysteine protease inhibitor. Enzymatic combinatorial biocatalysis creates a large compound library and leads to the ...

Antigen-presenting cells (APCs), such as dendritic cells and macrophages, are essential for initiating and regulation of anti-tumor T cell responses.

Chagas disease (CD) is a neglected tropical disease for which novel and improved treatments are needed. The cysteine protease Cruzipain is one of the main targets for the development of novel drugs ...

TMPZ also suppressed pyroptosis by inhibiting NLRP3 inflammasome activation and downregulating pyroptosis-related proteins (NLRP3,caspase-1, ASC ... and rehydrated through graded ethanol. After ...

To investigate the regulatory mechanisms of non-lethal function of caspase in the nervous system ... supplemented with cOmplete ULTRA EDTA-free protease inhibitor cocktail (#05892953001, Roche).

Here, we investigate the mechanisms of action of Δ133p53α and Δ160p53α isoforms using chromatin immunoprecipitation, luciferase expression, subcellular fractionation, immunofluorescence assays, and ...

During the early drug development stages of the COVID-19 pandemic, the SARS-CoV-2 cysteine protease M pro was identified as a potential target for novel therapeutics. Using high-throughput ...

Apoptosis is regulated by a family of cysteine-aspartyl proteases (caspases ... 10 after administration of drugs that block caspases. Caspase-3 is a prototypical group II effector caspase that ...

ASC then polymerizes to form a large aggregate known as an ASC speck. Polymerized ASC in turn interacts with the cysteine protease caspase-1 to form a complex termed as inflammasome. Active cytokines ...