However, it has proved difficult to engineer inhibitors of cysteine, serine or threonine proteases that do not contain an irreversible mechanism-based electrophile. This could be a matter of trial ...

Apoptosis is regulated by a family of cysteine-aspartyl proteases (caspases ... 10 after administration of drugs that block caspases. Caspase-3 is a prototypical group II effector caspase that ...