The high-potent oral solid dosage contract manufacturing market is gaining remarkable traction due to rising demand for safe and effective high-potency medications. As more pharmaceutical companies ...

The team discovered that, next to regions of fibrosis, there were high levels of the CTLA4 protein on a type of immune cell known as CD8-positive T-cells, also called cytotoxic T-cells. Cytotoxic ...

NK cells are cytotoxic; small granules in their cytoplasm contain special proteins such as perforin and proteases known as granzymes. Upon release in close proximity to a cell slated for killing ...

In a recent review published in the journal Nature Reviews Gastroenterology and Hepatology, researchers examine the multifaceted roles of neutrophils in inflammatory bowel disease (IBD) and ...

In the context of stress granules associated with neurodegenerative diseases ... the rigidification of liquid droplets for the low complexity domain of the Cytotoxic granule associated RNA binding ...

cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body’s defence against diseases. These specialised immune cells are ...

“As the granules arrive, their contents will be ... “We image the entire cytotoxic process. At the same time, because we control and know the exact pressure inside each of the micropipettes ...

As the granules arrive, their contents will be emptied ... "We image the entire cytotoxic process. At the same time, because we control and know the exact pressure inside each of the micropipettes ...

These organelles include lytic granules carrying a cargo of cytotoxic proteins packed on a proteoglycan scaffold, multivesicular bodies carrying the death receptor ligand FasL, and the recently ...

However, the classical lytic mode of NK activity, releasing cytotoxic granules that contain membrane-lysing peptides, would damage the host. Crespo and colleagues have recently described a new ...

To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of granzyme B, a key component of cytotoxic granules involved in T cell-mediated target cell-killing, ...