Disrupting the G-loop cycle causes transcriptome dysregulation and genome instability, revealing key role in cell survival and homeostasis.

And one of the things it can get stuck on is the DNA template itself, which can adopt alternative structures in certain contexts. For example, regions of the genome that are rich in guanine bases ...

Double trouble at chromosome ends Date: February 28, 2024 Source: Rockefeller University Summary: New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as ...

Their results corroborated earlier research, says Dr Stewart-Morgan: “We found that one DNA strand, the template or ‘parental’ strand, always has more hydroxymethylation than the other ‘daughter’ ...

To achieve this, your DNA must undergo a process called replication. When this occurs, the two DNA strands split apart. Then, specialized cellular proteins use each strand as a template to make a ...

DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene conversion with a short patch ...

Here, template unwinding and lagging‐strand replication continue at a decreased rate in the absence of leading‐strand synthesis (Taylor & Yeeles, 2018, 2019). In higher eukaryotes, repriming by a ...

Not much is known about these four-stranded DNA, known as G-quadruplexes — but now, scientists have developed a new way to detect these odd molecules and observe how they behave in living cells ...

Each A finds a U, each U finds an A, and C’s pair with G’s, so that the partners form a complementary strand, a template for making future copies of the original. The three reading frames on the ...

The ubiquitous presence of enzymes required for repair of DNA double strand breaks renders patients with defects in these pathways susceptible to ... HR operates predominantly in cells that are ...