The aggregation behaviors of silver atoms modulated by polymorphic DNA templates involving i-motif, G-quadruplex, and the Watson–Crick duplex, were investigated by using the density functional theory ...

Disrupting the G-loop cycle causes transcriptome dysregulation and genome instability, revealing key role in cell survival and homeostasis.

AbstractFocal amplifications of oncogenes are important cancer drivers. They can occur on chromosomes or in the context of circular extrachromosomal DNA (ecDNA). Many key features of ecDNAs were ...

Parallel-stranded (ps) DNA characterized by its sugar–phosphate backbones pointing in the same direction represents an alternative pairing system to antiparallel-stranded (aps) DNA with the potential ...

DNA replication is a fundamental process required of all cell types (1–3).Replicative polymerases (Pol), such as the leading-strand polymeraseε (Polε) and lagging-strand Polδ, synthesize DNA with ...

The only requirement for this rescue mechanism to work is that DnaA must form the initial sections of single-stranded DNA. A key insight from this study is that PriC only needs one of the two DnaA/DNA ...