Cardiac diastolic dysfunction (CDD), ultimately leading to heart failure with preserved ejection ... In this study, 12-month-old female mice were orally administered 50, 100 and 200 mg EGCG ...

In mice with HFpEF-like symptoms, metformin has shown potential ... Since its discovery in the late 1970s, understanding of titin’s role in heart function and disease has advanced significantly.

The data suggests that Hmga1, a key protein for regenerating heart cells, could be a target for gene therapies that prevent cardiac failure.

A cohort study found that patients with rheumatoid arthritis had an increased risk for heart failure, particularly with ...

The researchers found that heart failure with preserved ejection fraction (HFpEF) was the most common heart failure subtype in both groups (65% in RA versus 59% in non-RA). Patients with RA had a ...

Faun1083 has demonstrated positive in-vivo efficacy in multiple preclinical animal models, including rat sugen hypoxia and ZSF1 studies, which are common models to study key features of heart failure ...

In a large-animal model study, researchers have found that heart attack recovery is aided by the injection of heart muscle cell spheroids derived from human-induced pluripotent stem cells (hiPSCs), ...

The administration of potassium nitrate (KNO3) does not improve exercise capacity or quality of life in patients with heart failure with preserved ejection fraction (HFpEF), despite increasing ...

The challenge for Bayer will be carving out a role for Kerendia in mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF) heart failure alongside SGLT2 inhibitors – AstraZeneca's Farxiga ...

Dr. Kevin Watt, team leader of the Heart ... in mice, pigs and sheep. "The vision of our research is to develop new therapies that can transform the lives of children with heart failure." ...