Moxifloxacin inhibits topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. ≥18yrs: 400mg once daily.

Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

triazaacenaphthylene antibacterial that inhibits bacterial DNA replication by a distinct binding site and unique mechanism of action, resulting in the well-balanced inhibition of two different type II ...