A new lipid-based pathway essential for memory formation has been discovered by University of Queensland researchers—a ...

Purpose Prior evidence suggests that kynurenine pathway (KP) metabolites and peripheral inflammatory ... We tested the hypotheses that HC use moderates associations of KP metabolites (kynurenic acid ...

In an interview with former Fox News journalist Megyn Kelly, FDA Commissioner Marty Makary introduced a new mechanism-driven pathway that could be leveraged by rare disease therapies while saying that ...

Plasma tryptophan and downstream metabolites of the kynurenine pathway were quantified using the targeted ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ...

The kynurenine pathway may explain why teenage girls are more prone ... and another that leads to the production of neurotoxic substances. Key byproducts include kynurenic acid, which protects brain ...

The 'kynurenine pathway' is a series of chemical reactions ... This process involves several byproducts including kynurenic acid (neuroprotective) and quinolinic acid (neurotoxic).

Type I and II interferons (IFNs) stimulate the KYN/TRP pathway, producing elevated QA/kynurenic acid (KA), a potential neurotoxic imbalance that may contribute to SLE-mediated cognitive dysfunction.

The transcription factor HIF‐1α has a role in the tryptophan/NAD + pathway that ensures redox homeostasis of resting Natural Killer (NK) cells. Upon activation, forced HIF‐1α‐driven glycolysis ...

Animal models of epileptic spasms have shown decreased brain kynurenic acid, which is increased after treatment with the ketogenic diet. We quantified kynurenine pathway metabolites in the ...