Analysis from continued follow-up of Phase 1/2 clinical trial data in Hunter syndrome (MPS II) reinforces potential for tividenofusp alfa (DNL310) to address full disease spectrumLaunch readiness ...
Findings revealed biological pathways as potential intervention points, and demonstrated in fruit flies potential therapeutic strategies.
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting more than 10 million people ...
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting more than ...
Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.
Using LysoTag and proteomics, scientists built the first atlas of lysosomal proteins across neurons, astrocytes, microglia, ...
Together with colleagues from Stanford University, USA, researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) have, for the first time, created a comprehensive cell ...
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder. Ali Ghoochani, Julia C. Heiby, Eshaan S. Rawat, Uche N. Medoh, Domenico Di Fraia, ...
Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...
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