The first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other ...

It includes the WS compounds and considers more broadly the basic structure of menthol and the chemical groups that are added to it. Belgium and the Netherlands consider function in their bans.

In a collaborative effort, researchers at the University of Amsterdam and the HFML-FELIX institute in Nijmegen have been able ...

Imidazoles and triazoles are essential chemical compounds used in many medicines, including drugs used to defeat various ...

In 2020 lawmakers in California and Massachusetts banned menthol, a chemical that causes a cooling sensation, as an additive in cigarettes. The idea was partly to help curb youth smoking; menthol ...

Using cryo-electron microscopy, which enables visualization of frozen molecular structures at high resolution, the team analyzed this unique complex at a resolution of 3.66 Å ...

We applaud the recent action by the Biden administration to restrict the sales of menthol cigarettes and flavored cigars.In this article, we review the rationale for a ban and offer ...

Researchers have found a small change in a gene called MRGPRX4 that is linked to a significant increase in the preference for menthol cigarettes. The genetic variant was identified only in people of ...

Figure 1: Selected oxidation products of (–)-menthol and calculated bond dissociation energies for the corresponding C–H bonds (in kcal mol −1). Table 1 Persistence of the potential salt ...

With the help of a protein with the catchy name of phosphatidylinositol-4,5-bisphosphate (PIP 2) menthol binds to TRPM8 perfectly, like a tiny minty key for the cellular lock that is the ion channel.

"Knowing the atomic structure of TRPM8 and how it reacts to cold, menthol and other stimuli should help in the design of potent and selective new drugs targeting this sensor," said study leader ...