Niclosamide’s development as an antiviral has been held back by its low absorption and short half-life, which Hyundai Bio claims to have solved using a proprietary, polymeric drug delivery ...

Some of the most toxic drugs to MCF7 cells included disulfiram, quinacrine, niclosamide, and dipyridamole. Disulfiram had the lowest IC50 value, meaning it required only a small dose to reduce cell ...

The weight of niclosamide required for each application was derived from estimates of pool volumes assuming that the contours of pools approximated a segment of a sphere. The volume of water in each ...

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Introduction There are persistent gaps in access to affordable medicines. The WHO Model List of Essential Medicines (EML) includes medicines considered necessary for functional health systems.Methods ...

2018Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiotaNat Commun 9:5233 Google Scholar 51. Tam J et al. 2020Intestinal bile ...

Selection of an appropriate salt form for a new chemical entity provides the pharmaceutical chemist and formulation scientist with the opportunity to modify the characteristics of the potential drug ...

Cancer metastasis is difficult to treat, and its outcome becomes dreadful for a patient. Lung is a major metastatic site for many types of cancers, and the need for finding effective treatment for ...

When a drug fails late on in clinical trials it’s a major setback for launching new medicines. It can cost millions, even billions, of research and ...