Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

In vitro, nitazoxanide has shown excellent activity against C. difficile. In one study, the 90% MIC (MIC 90) of the toxigenic strains of C. difficile was 0.5 µg/mL for nitazoxanide, which was ...

Objective: To describe emergent therapies, such as rifaximin, nitazoxanide, intravenous immunoglobulin (IVIG), tinidazole, tolevamer, and the possible use of a vaccine, in Clostridium difficile ...

Earthworms reveal an evolutionary mechanism which could defy Darwin A comparative genome study of earthworms and their marine relatives could challenge Darwin’s theory of evolution by showing ...

The C(sp3)–C(sp3) desaturation catalyzed by iron(II)- and 2-(oxo)glutarate-dependent(Fe/2OG) oxygenase is a key step in the biosynthesis and modification of natural products. Similar to other C–H ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

Efficient seawater oxidation reaction is crucial for advancing hydrogen fuel production. Developing highly efficient oxygen evolution reaction (OER) catalysts that follow the lattice oxygen mechanism ...