Dr. Geballe affirmed his lab’s future efforts: “We are continuing to try to understand the drug’s antiviral mechanism since it might be a useful target for broadly acting antiviral drugs.” Hickson SE, ...

The presumed mechanism of action of nitazoxanide is inhibition of pyruvate-ferredoxin oxidoreductase, an enzyme essential to anaerobic energy metabolism. In vitro, nitazoxanide has shown excellent ...

Nitazoxanide is effective against the influenza virus due to its impact on post-translational modification and maturation of hemagglutinin. A recent study reported a similar mechanism involving ...

Adding nitazoxanide to standard of care for the treatment of children and adults with severe acute respiratory infections was safe, but it did not reduce hospital stay, complications like ...

Despite promising in vitro results and new hypotheses on its antiviral mechanism, NTZ failed to reduce the severity of SARS-CoV-2 infection in vivo in the Syrian hamster model.” Results ...

Currently, nitazoxanide is the only FDA-approved drug for cryptosporidiosis. However, ... However, other mechanisms are also thought to be responsible that have not been elucidated yet.

To identify a mechanism of action for killing; To identify the MIC of the drug . Published Papers: Harausz EP, Chervenak KA, Good CE, Jacobs MR, Wallis RS, Sanchez-Felix M, Boom WH, TB Research Unit ...

Romark announced results from its Phase 2 trial of nitazoxanide in treatment-naive patients with genotype 1 chronic hepatitis C. This study, named STEALTH C-3, was a randomized, double-blind ...