Fujifilm Validates Cancer Cell-Targeting Potential of Peptide Oligonucleotide Conjugates with Novel Cyclic Peptides. Research highlights to be presented at TIDES USA 2025.

Cyclic peptides, which combine characteristics of both small molecules and proteins, have emerged as significant molecules for regulating protein–protein interactions (PPIs).

Breakthrough in creating cyclic peptide opens the way for new antibiotics Date: June 10, 2024 Source: King's College London Summary: A discovery could speed up efforts to produce new antibiotics ...

Some are formed of cyclic peptides – strings of amino acids joined together in a circle – which are very difficult to replicate in the lab. To understand how this process occurs in nature, ...

Keywords: cyclic peptide, cysteinyl prolyl ester, native chemical ligation, RGD, inhibitor. Citation: Yamada A, Takei T, Kawakami T, Taniguchi Y, Sekiguchi K and Hojo H (2024) Application of cysteinyl ...

Considering that orally administered cyclic peptides generally show a bioavailability below 2%, an oral bioavailability of 18% is a substantial advance for peptide-based biologic drugs.

A cyclic peptide is a type of organic molecule that consists of amino acids linked together in a circular or lariat shape. What makes them particularly attractive is that they can target intracellular ...

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology.

As a unique molecular class, cyclic peptides have attracted increasing attention, among which natural peptides are the main sources of approved cyclic peptides in the last century. In the past 20 ...

In a study (“Large-Scale Membrane Permeability Prediction of Cyclic Peptides Crossing a Lipid Bilayer Based on Enhanced Sampling Molecular Dynamics Simulations”) published in the Journal of ...

Supercomputer predicts cell-membrane permeability of cyclic peptides Date: July 13, 2021 Source: Tokyo Institute of Technology Summary: Scientists have developed a computational method based on ...