When scientists sequence tumor DNA, they typically find small amounts of genetic code from bacteria, viruses and fungi – microorganisms that, if actually present in tumor tissues, could influence how ...

Interpretation is the discipline through which molecular datasets reveal their significance. As the life sciences enter a new era defined by data richness and technological capacity, interpretive ...

Immunotherapy has been a revolutionary breakthrough for cancer therapeutics, but it is still hampered in that it only benefits certain patients. Moreover, the molecular determinants of immunotherapy ...

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

Abstract: RNA sequencing has become an essential technique in the life sciences, providing a comprehensive methodology. RNA sequencing has become an essential method in the life sciences, providing a ...

notebooks_2020_10_08_bulk_RNAseq_pathwayAnalysis.ipynb - a bulk RNAseq analysis tutorial I wrote using kallisto quantified data (R) youtube link for a walkthrough of ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...

Essentially all cells in an organism's body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it ...

Abstract: Accurately identifying differentially expressed genes from time-course RNA-Seq data is essential for understanding the dynamics of transcriptome changes during biological processes. Although ...