Protein folding helpers such as TRiC and prefoldin (PFD) are crucial for the correct folding of many essential proteins. In a Nature study, researchers from the Max Planck Institute of Biochemistry ...
This image highlights two alternatives for the ribosome to be recruited to an mRNA that is still being synthesized by RNA polymerase (RNAP). RNAP (left, red) can directly deliver the mRNA to the entry ...
Gcn2 is a critically important protein kinase of the integrated stress response (ISR) pathway and is conserved from yeast to humans. Although Gcn2 has long been known to interact with 60S subunits, ...
Building on previous work from the Tansey lab, here Howard et al. characterize transcriptional and translational changes upon WIN site inhibition of WDR5 in MLL-rearranged cancer cells. They first ...
Researchers at LMU and Stanford University reveal how cells regenerate protein factories at endoplasmic reticulum. The synthesis of proteins in the cell is a key process of life. By this means, the ...
1 Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston, MA, United States 2 Genome Science Institute, Chobanian and Avedisian School of Medicine, Boston, MA, ...
New high-resolution images have provided insights into how the large subunit of human ribosomes assembles, advancing our understanding of these essential cellular machines. The findings, which ...
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