Articles were selected for inclusion if they reported on patients with metastatic prostate cancer who received a germline or somatic genomic test and/or made comparisons between those tests, reported ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter.

(A) Hypothetical pedigree of Segmental neurofibromitosis type 1, and (below) molecular analysis showing somatic mosaicism ... molecular analysis showing germ-line mosaicism in tuberous sclerosis.

He adds, “it’s not clear that the mutation rate differs between somatic vs. germline . . . and if it does not, then nothing is gained or lost” in terms of how much variation parents are providing to ...

Precision medicine is transforming nursing roles in clinical oncology, and nurses play an increasingly crucial role in implementing personalized therapy and improving patient outcomes.

This process is commonly reverted in cancer cells (i.e. a soma-to-germline transition) and is intentionally reversed when mammalian somatic cells are reprogrammed into induced Pluripotent Stem Cells.

A germ-line mutation looks like a red ball in a sea of white balls—difficult, but not impossible, to spot; a somatic mutation is gray, and more easily blends in. “In genetics, it can be hard ...