Mismatch repair (MMR) germline alterations are enriched among patients with uveal melanoma (UM), according to a study ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...

It is estimated that up to one-third of mutations identified through tumor-only sequencing may be false-positive germline changes, including those in actionable genes. 1 ...

A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical ...

Patients with metastatic prostate cancer should undergo both germline and somatic DNA sequencing using panel-based assays. These tests can guide the use of poly (ADP-ribose) polymerase inhibitors, ...

Now, with our germline testing and variant assessment expertise behind Tempus xG and xG+, we are poised to create a future where paired somatic and germline testing is the standard.

Although the literature reports that inherited mutations are thought to play a role in approximately 5% to 10% of all cancers. Recent data, including those of the Intercept Somatic (IRB 18-00326) ...

Somatic mutations are, by definition, mutations that do not affect sex cells, so they are not inheritable. RNMSM prevalence was found to increase with age, as might be expected, with an average 50 ...

Somatic human genome editing has made huge strides in the past five years, but the likely extremely high prices will be unsustainable. A global commitment to affordable, equitable access is urgently ...

We have a discussion about what’s a germline mutation and what’s a somatic mutation and what can we act on. We want to know about the available therapies. For some of these genes, often there are ...

After the initial discovery of somatic STAT3 mutations, germline STAT3 mutations were discovered in children with severe autoimmunity and large granular lymphocyte lymphoproliferation. 93 ...