The 49ers are likely to be without George Kittle, Christian McCaffrey and Deebo Samuel for Sunday's game at the Rams.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Greg Papa joins "49ers Talk" host Matt Maiocco and discusses if 49ers wide receiver Brandon Aiyuk will step up in Rams ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

Heading down to Southern California for the first time in the 2024 season, the San Francisco 49ers will be shorthanded when ...

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday's game against the Los Angeles Rams ...

San Francisco 49ers running back Christian McCaffrey will be eligible off the injured reserve after Week 6, but could still miss a pivotal Week 7 Super Bowl rematch with the Kansas City Chiefs.

George Kittle, Deebo Samuel, and Christian McCaffrey have all scored multiple touchdowns in the 49ers’ recent visits to SoFi Stadium.

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.