Naloxone - Wikipedia
Naloxone is an opioid antagonist: a medication used to reverse or reduce the effects of opioids. [13] For example, it is used to restore breathing after an opioid overdose. It is also known as Narcan. [13] Effects begin within two minutes when given intravenously, five minutes when injected into a muscle, [13] and ten minutes as a nasal spray. [14]
Naloxone | C19H21NO4 | CID 5284596 - PubChem
Naloxone is an opioid receptor antagonist indicated in the reversal of opioid overdoses. Naloxone has a shorter duration of action than opioids and multiple doses may be required. The therapeutic window of naloxone is wide, as it has no effect if a patient has not taken opioids.
Naloxone - StatPearls - NCBI Bookshelf - National Center for ...
May 5, 2024 · Naloxone has been used as an antidote to opioids for over 50 years, and the drug has been readily available as a parenteral formula. Naloxone acts as a pure μ-opioid receptor competitive antagonist and is instrumental in preventing accidental overdose of opioids.
Naloxone: Uses, Interactions, Mechanism of Action - DrugBank …
Naloxone is an opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Mar 14, 2024 · Naloxone acts by competitive displacement of opioid agonists at the μ-opioid receptor (MOR). Its effect depends on pharmacological characteristics of the opioid agonist, such as dissociation rate from the MOR receptor and constitution of the victim.
Naloxone | Magnificent molecules - RSC Education
Oct 10, 2018 · Naloxone’s core molecular structure is that of a classic opioid, but has no painkilling or euphoria-inducing properties. Since 1971, naloxone has been approved to treat overdoses. However, the antidote only works if it administered quickly.
Naloxone Hydrochloride | C19H22ClNO4 | CID 5464092 - PubChem
Naloxone Hydrochloride is the hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical ...
Naloxone - NIST Chemistry WebBook
Chemical structure: This structure is also available as a 2d Mol file. Stereoisomers: Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17- (2-propenyl)-, (5α)-. Other names: (5α)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride. Permanent link for this species.
naloxone | C19H21NO4 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for naloxone, 465-65-6, Evzio.
Naloxone - an overview | ScienceDirect Topics
Naloxone is a few times stronger than nalorphine as an antagonist. It blocks opiate receptors. It eliminates central and peripheral action of opioids, including respiratory depression. Naloxone is used upon overdose of narcotic analgesics.Synonyms for this drug are narkan, talwin, and others.