Structural organization of the endoplasmic reticulum
The endoplasmic reticulum (ER) is a continuous membrane system but consists of various domains that perform different functions. Structurally distinct domains of this organelle include the nuclear envelope (NE), the rough and smooth ER, and the regions that contact other organelles. The establishment of these domains and the targeting of ...
Human brain organoids and their ethical issues: - EMBO reports
Dec 15, 2023 · Organoid research has recently turned ten years old and has shown itself to be one of the most promising areas of biomedical research. Since the first protocol for developing brain organoids was published in 2013 (Lancaster et al, 2013), researchers have used them to study a variety of normal and pathological conditions, effects of viruses on the human central nervous system or effects of ...
Strigolactones promote plant freezing tolerance by releasing the
Aug 25, 2023 · Cold stress is a major abiotic stress that adversely affects plant growth and crop productivity. The C‐REPEAT BINDING FACTOR/DRE BINDING FACTOR 1 (CBF/DREB1) transcriptional regulatory cascade plays a key role in regulating cold acclimation and freezing tolerance in Arabidopsis (Arabidopsis thaliana).Here, we show that max (more axillary growth) mutants deficient in strigolactone ...
A rare human centenarian variant of SIRT6 enhances genome …
SIRT6 is localized in the nucleus where it interacts with nuclear scaffold protein Lamin A/C (LMNA) (Ghosh et al, 2015), which is also implicated in human longevity.Mutations in LMNA cause a multitude of human genetic syndromes, many of them associated with premature aging, including Hutchinson Gilford progeria syndrome (HGPS) (De Sandre‐Giovannoli et al, 2003; Eriksson et al, 2003).
MCM8 interacts with DDX5 to promote R-loop resolution
Jun 10, 2024 · In Mcm8−/− PGCs, the impaired interaction of MCM8 with DDX5 and DHX9 leads to reduced R-loop removal. Unscheduled R-loop accumulation increases genome instability and ultimately leads to PGC proliferation defects. Data information: Asterisk (*) indicates a non-specific band of IgG heavy chain.
Dinoflagellate mRNA is pervasively modified with m1A | EMBO …
Sep 20, 2024 · Li et al first quantified m 1 A stoichiometry in the dinoflagellate species Amphidinium carterae (A. carterae) by mass spectrometry.The authors found that m 1 A is surprisingly abundant in A. carterae mRNA, with up to 3.05% adenosines being modified. This is remarkably high for an mRNA modification. In comparison, m 6 A, the most prevalent mRNA modification in many species, normally accounts ...
Liver protects neuron viability and electrocortical activity in post ...
Sep 19, 2024 · Mortality after CA is mainly triggered by post-CA shock and brain injury (Laver et al, 2004).Following the return of spontaneous circulation, the whole-body ischemia-reperfusion response leads to the post-CA syndrome, comprising post-CA brain injury, myocardial dysfunction, systemic ischemia-reperfusion response, and persistent precipitating pathology, resulting in significant morbidity and ...
Transplacental SARS-CoV-2 protein ORF8 binds to complement …
Oct 10, 2024 · Infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over the past four years resulted in nearly 800 million cases and 7 million deaths worldwide, with continued cases and mortality occurring even after the public health emergency declaration for Coronavirus disease 2019 (COVID-19) ended in …
The Wnt signaling protein BCLL is upregulated in soft tumor cells and regulates their. 9. stemness and tumorigenicity. Clinically, BCLL expression is corre-. 9. lated with a worse prognosis. Our findings suggest that the intrin-sic softness is a unique marker of highly tumorigenic and metastatic tumor cells.
Systemic gene therapy rescues retinal dysfunction and hearing …
Aug 29, 2023 · Norrie disease is a rare recessive X‐linked dual sensory disorder, caused by mutations in the Norrie Disease Pseudoglioma (NDP) gene and manifests as congenital blindness and progressive hearing loss (Fradkin, 1971; Holmes, 1971; Chen et al, 1992; Berger et al, 1992a,b).Vision loss is caused by underdevelopment of the deep retinal vasculature, resulting in hypoxia and tractional retinal ...