Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ ...
Aug 2, 2023 · Soluble epoxide hydrolase (sEH) is expressed in both peripheral tissues and CNS. Its upregulation has been implicated in multiple neurological conditions, including depression, …
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse ...
Dec 15, 2020 · Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27;8 (1):5279. PubMed. O'Brien CE, Santos PT, Kulikowicz E, Lee JK, …
Epoxide Hydrolase, a Fat New Target for Alzheimer’s Therapy?
Dec 15, 2020 · Given that epoxide hydrolase inhibitors are already being tested in the clinic for other conditions, they may have the potential to become a new class of AD drug. Darryl Zeldin, National …
Genetic deletion of soluble epoxide hydrolase delays the progression …
Lee HT, Lee KI, Chen CH, Lee TS. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16 (1):267. PubMed. Recommends …
New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
Oct 24, 2023 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and into the brain, …
Dysregulated Lipid Metabolism Comes to the Fore at AD/PD
Apr 27, 2023 · To explore how GBA1 and APOE influence brain lipid homeostasis, Isacson and colleagues treated wild-type and APOE knockout mice with the GBA1 inhibitor conduritol b epoxide …
Society for Neuroscience Annual Meeting 2019 | ALZFORUM
In mice fed the GCase inhibitor conduritol β epoxide (CBE), PR001 injected into the brain ventricles beefed up GCase activity and reduced glycolipid accumulation, which is a sign that lysosomes are …
Gba1 D409V KI Mouse (Grabowski) | ALZFORUM
Jul 16, 2024 · This knock-in (KI) mouse model was generated by introducing a c.A1366T point mutation into exon 9 of the mouse Gba1 (acid β-glucosidase) gene resulting in a D409V substitution (Xu et al., …
Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
Jul 1, 2011 · Instead of a knockdown approach, the researchers used conduritol B epoxide (CBE) to chemically inhibit GBA in PC12 neuronal cells expressing wild-type α-synuclein. Unlike the MGH …
Time to Try Again: Gene-Based Therapy for Neurodegeneration
In mice fed the GCase inhibitor conduritol β epoxide (CBE), PR001 injected into the brain ventricles beefed up GCase activity and reduced glycolipid accumulation, which is a sign that lysosomes are …