Dec 13, 2021 · Normal T cell development in the thymus undergoes a major developmental checkpoint in which T cell receptor (TCR) signaling is involved.

Upon binding to pMHC, the TCR initiates a signaling cascade, involving transcription factor activation and cytoskeletal remodeling resulting in T-cell activation.

2 days ago · T Cell Receptor (TCR) activation promotes a number of signaling cascades that ultimately determine cell fate through regulating cytokine production, cell survival, proliferation, …

The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically.

May 21, 2025 · Collectively, these studies provide compelling evidence that TCR signaling has a deterministic impact on T cell fate. This review summarizes recent advances in understanding …

Aug 29, 2024 · This article delves into the intricacies of TCR structure, function, signaling pathways, and testing methodologies, providing a comprehensive overview supported by the …

Feb 6, 2025 · This topic briefly reviews signaling through the TCR complex, identifying the proteins involved and highlighting downstream targets of the signaling cascade. TCR genetics, …

Explore the complete T-cell receptor signaling cascade from antigen recognition to gene expression. Learn how TCR/CD3 complex, LAT signalosome, and calcium signaling regulate T …

Normal T cell development in the thymus undergoes a major developmental checkpoint in which T cell receptor (TCR) signaling is involved.

May 21, 2020 · In this review, we summarize current knowledge on the pathways that govern how the TCR complex transmits signals into cells and the roles of effector molecules that are …