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SOLVED: 2. The three molecules shown below are all potent 5-HT receptor antagonists. (a) (b) (c) 3. The following is the structure of lumiracoxib, a COX-2 selective NSAID. (a) Design a pharmacophore for 5-HT antagonism that is consistent with the three structures and identify which part of each molecule represents each pharmacophoric element. (6 marks) (b) Using the given structures for the three 5-HT antagonists, design three different molecules that test your pharmacophore hypothesis. (6 marks

SOLVED: 2. The three molecules shown below are all potent 5-HT receptor antagonists. (a) (b) (c) 3. The following is the structure of lumiracoxib, a COX-2 selective NSAID. (a)

numerade.com11 months ago

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